CDX2 EXPRESSION IN GASTROINTESTINAL TUMOURS

Expression of gastrointestinal endocrine tumours in culture systems.

Human endocrine tumours were studied in in vitro systems (cell suspensions and tissue cultures) and in in vivo systems (tumour transplants to the anterior eye-chamber of immunosuppressed rats). In the experimental systems the tumour cells were demonstrated to synthesize and secrete the same hormonal products as in the patient. Intraocular transplants of a gastrinoma secreted gastrin-17 into the...

Neuroendocrine gastrointestinal tumours.

Neuroendocrine gut and pancreatic tumours have provided a diagnostic and therapeutic challenge over the years. These rather slowly growing neoplasms have been assigned a good prognosis but when liver metastases are present the prognosis is not better than that of most other malignant tumours. Despite the development of improved diagnostic procedures many patients are still referred at a stage o...

Gastrointestinal stromal tumours (GIST)

Laparoscopic staging of gastrointestinal tumours.

management of those problems. Only with a complete knowledge of the staging of the disease can the appropriate treatment be applied, be it surgical or medical. Many of the approaches for this pre-operative (or “non operative”) staging are based in imaging exams that have shown, up till now, some degree of failure in its results. This is due to a lack of definition, both in dimensions and in his...

Gastrointestinal Carcinoid Tumours: A Review

Introduction: Carcinoid tumour represents the majority of the neuroendocrine malignancy of the gastrointestinal tract. Diagnosis is difficult as it is often asymptomatic and non-specific, and the presence of symptoms generally implies advanced disease. Whilst surgical resection remains the treatment of choice for primary and respectable disease, there are still significant uncertainties for man...